From Chemistry Towards Technology Step-By-Step From Chemistry Towards Technology Step-By-Step От химии к технологии шаг за шагом 2782-1900 92010 10.52957/2782-1900-2024-5-4-134-141 Научные статьи Scientific articles Научные статьи Selective modification of tetrahydrochromeno[2,3-d]pyrimidin-2-ones Selective modification of tetrahydrochromeno[2,3-d]pyrimidin-2-ones Макарова Елена Сергеевна Makarova Elena Sergeevna makarovaes@ystu.ru

кандидат химических наук;

candidate of chemical sciences;

 Чиркова Жанна Вячеславовна Chirkova Zhanna Vyacheslavovna chirkovazhv@ystu.ru

доктор химических наук;

doctor of chemical sciences;

 Урядова Анастасия Михайловна Uryadova Anastasia Mikhailovna Карандеева Алена Сергеевна Karandeeva Alena Sergeevna Богданова Наталья Андреевна Bogdanova Natalya Andreevna Ярославский государственный технический университет Yaroslavl State Technical University 23 12 2024 23 12 2024 5 4 134 141 06 11 2024 19 11 2024 https://ystu.editorum.ru/en/nauka/article/92010/view

The paper presents the results of the synthesis and characterisation of seven new tetrahydrochromeno[2,3-d]pyrimidin-2-ones derivatives obtained by selective modification of the hydroxyl group at the C-8 position. The authors successfully used alkylation and acetylation reactions to introduce substituents into the molecule. This resulted in a series of new heterocyclic compounds with yields up to 94 %. The authors characterised the obtained compounds by NMR spectroscopy (¹H and ¹³C) and mass spectrometry.

The paper presents the results of the synthesis and characterisation of seven new tetrahydrochromeno[2,3-d]pyrimidin-2-ones derivatives obtained by selective modification of the hydroxyl group at the C-8 position. The authors successfully used alkylation and acetylation reactions to introduce substituents into the molecule. This resulted in a series of new heterocyclic compounds with yields up to 94 %. The authors characterised the obtained compounds by NMR spectroscopy (¹H and ¹³C) and mass spectrometry.

 tetrahydrochromeno[2 3-d]pyrimidin-2-ones methyl iodide acetic anhydride alkylation acylation

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