From Chemistry Towards Technology Step-By-Step From Chemistry Towards Technology Step-By-Step От химии к технологии шаг за шагом 2782-1900 92001 10.52957/2782-1900-2024-5-4-58-65 Научные статьи Scientific articles Научные статьи Selektivnaya modifikaciya tetragidrohromeno[2,3-d]pirimidin-2-onov Селективная модификация тетрагидрохромено[2,3-d]пиримидин-2-онов Макарова Елена Сергеевна Makarova Elena Sergeevna makarovaes@ystu.ru

кандидат химических наук;

candidate of chemical sciences;

 Чиркова Жанна Вячеславовна Chirkova Zhanna Vyacheslavovna chirkovazhv@ystu.ru

доктор химических наук;

doctor of chemical sciences;

 Урядова Анастасия Михайловна Uryadova Anastasia Mikhailovna Карандеева Алена Сергеевна Karandeeva Alena Sergeevna Богданова Наталья Андреевна Bogdanova Natalya Andreevna Ярославский государственный технический университет Yaroslavl State Technical University 23 12 2024 23 12 2024 5 4 58 65 06 11 2024 19 11 2024 https://ystu.editorum.ru/en/nauka/article/92001/view

В данной работе представлены результаты синтеза и характеристики семи новых производных тетрагидрохромено[2,3-d]пиримидин-2-онов, полученных путем селективной модификации гидроксильной группы в положении С-8. Реакции алкилирования и ацетилирования были успешно использованы для введения заместителей в молекулу, что позволило получить серию новых гетероциклических соединений с выходами до 94 %. Характеристика полученных соединений проведена методами ЯМР-спектроскопии (¹H и ¹³C), а также масс-спектрометрии.

В данной работе представлены результаты синтеза и характеристики семи новых производных тетрагидрохромено[2,3-d]пиримидин-2-онов, полученных путем селективной модификации гидроксильной группы в положении С-8. Реакции алкилирования и ацетилирования были успешно использованы для введения заместителей в молекулу, что позволило получить серию новых гетероциклических соединений с выходами до 94 %. Характеристика полученных соединений проведена методами ЯМР-спектроскопии (¹H и ¹³C), а также масс-спектрометрии.

 тетрагидрохромено[2 3-d]пиримидин-2-оны иодистый метил ангидрид уксусной кислоты алкилирование ацилирование

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