From Chemistry Towards Technology Step-By-Step From Chemistry Towards Technology Step-By-Step От химии к технологии шаг за шагом 2782-1900 81496 10.52957/2782-1900-2024-4-3-69-75 Научные статьи Scientific articles Научные статьи Synthesis of condensed morpholine-containing systems by reductive or oxidative heterocyclisation Synthesis of condensed morpholine-containing systems by reductive or oxidative heterocyclisation Савина Луиза Ильинична Savina Luisa Ilyinichna luizasavina2000@mail.ru Соколов Александр Андреевич Sokolov Aleksandr Andreevich Ярославский государственный медицинский университет Yaroslavl State Medical University Ярославский государственный университет им. П.Г. Демидова P.G. Demidov Yaroslavl State University Ярославский государственный технический университет Yaroslavl State Technical University 23 09 2023 23 09 2023 4 3 69 75 08 09 2023 15 09 2023 https://ystu.editorum.ru/en/nauka/article/81496/view

The article examines the reduction of N (2,4 dinitrophenyl)morpholine in acidic medium by tin (II) chloride. Under these conditions there is a formation of a mixture of products of reduction, chlorination and heterocyclisation reactions. The authors developed a method for the preparation of condensed 3,4 dihydro-1H-benzo[4,5]imidazo[2,1-c][1,4]oxazines by reduction of (2-nitro-4-R-phenyl)morpholine into 5-R-2-piperidin-1-ylanilines followed by oxidative heterocyclisation with supramuravic acid.

The article examines the reduction of N (2,4 dinitrophenyl)morpholine in acidic medium by tin (II) chloride. Under these conditions there is a formation of a mixture of products of reduction, chlorination and heterocyclisation reactions. The authors developed a method for the preparation of condensed 3,4 dihydro-1H-benzo[4,5]imidazo[2,1-c][1,4]oxazines by reduction of (2-nitro-4-R-phenyl)morpholine into 5-R-2-piperidin-1-ylanilines followed by oxidative heterocyclisation with supramuravic acid.

 N-(2-nitro-4-R-phenyl)morpholines 3 4-dihydro-1H-benzo[4 5]imidazo[2 1-c][1 4]oxazines reductive heterocyclisation oxidative heterocyclisation

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