From Chemistry Towards Technology Step-By-Step From Chemistry Towards Technology Step-By-Step От химии к технологии шаг за шагом 2782-1900 119502 10.52957/2782-1900-2026-7-1-125-135 Научные статьи Scientific articles Научные статьи Synthesis of 2,4,7,9-tetraphenyl-4,4a,9,9a-tetrahydrothiopyrano[2,3-g]thiochromene-5,10(5aH,10aH)-dione and analysis of its biological activity Synthesis of 2,4,7,9-tetraphenyl-4,4a,9,9a-tetrahydrothiopyrano[2,3-g]thiochromene-5,10(5aH,10aH)-dione and analysis of its biological activity Немиров Даниил Михайлович Nemirov Daniil Mihaylovich dmnemirov@bk.ru Овчинников Константин Львович Ovchinnikov Konstantin L'vovich

кандидат химических наук;

candidate of chemical sciences;

 Ярославский государственный технический университет Yaroslavl State Technical University 02 04 2026 02 04 2026 7 1 125 135 29 01 2026 16 03 2026 https://ystu.editorum.ru/en/nauka/article/119502/view

2,4,7,9-Tetraphenyl-4,4a,9,9a-tetrahydro-thiopyrano[2,3-g]thiocromene-5,10(5aH,10aH)-dione has been synthesised. Molecular docking with the GABAB(1) receptor was performed, and its affinity and toxicity were calculated. Computational studies were conducted using the PASS-Online programme to identify substance biological activities.

2,4,7,9-Tetraphenyl-4,4a,9,9a-tetrahydro-thiopyrano[2,3-g]thiocromene-5,10(5aH,10aH)-dione has been synthesised. Molecular docking with the GABAB(1) receptor was performed, and its affinity and toxicity were calculated. Computational studies were conducted using the PASS-Online programme to identify substance biological activities.

 2H-thiopyranes molecular docking Diels–Alder heterocyclic reaction GABAB(1) receptor affinity toxicity PASS-Online

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