From Chemistry Towards Technology Step-By-Step From Chemistry Towards Technology Step-By-Step От химии к технологии шаг за шагом 2782-1900 81518 10.52957/2782-1900-2024-4-2-66-71 Научные статьи Scientific articles Научные статьи Diastereoselective synthesis of chromeno[4,3-d]pyrimidines Diastereoselective synthesis of chromeno[4,3-d]pyrimidines Урядова Анастасия Михайловна Uryadova Anastasia Mikhailovna Макарова Елена Сергеевна Makarova Elena Sergeevna makarovaes@ystu.ru

кандидат химических наук;

candidate of chemical sciences;

 Филимонов Сергей Иванович Filimonov Sergey Ivanovich

доктор химических наук;

doctor of chemical sciences;

 Ярославский государственный технический университет Yaroslavl State Technical University 23 06 2023 23 06 2023 4 2 66 71 28 04 2023 12 05 2023 https://ystu.editorum.ru/en/nauka/article/81518/view

The paper investigates the diastereoselective synthesis of chromeno[4,3-d]pyrimidines by isolation and cyclization of diastereomerically pure dihydropyrimidine addition intermediates to resorcinol. The authors discovered the reversibility of the addition reaction to be an important factor that could neutralize the dominant formation of one of the intermediate diastereomers.

The paper investigates the diastereoselective synthesis of chromeno[4,3-d]pyrimidines by isolation and cyclization of diastereomerically pure dihydropyrimidine addition intermediates to resorcinol. The authors discovered the reversibility of the addition reaction to be an important factor that could neutralize the dominant formation of one of the intermediate diastereomers.

 hexahydrochromeno[4 3-d]pyrimidines resorcinol acid-catalyzed condensation diastereoselectivity

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